Tianjin Chase Sun Pharmaceutical Co., Ltd

Rocuronium CAS Registry Number: 143558-00-3 CAS Name: 1-[(2,3,5,16,17)-17-(Acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl]-1-(2-propenyl)pyrrolidinium Additional Names: 1-allyl-1-(3,17-dihydroxy-2-morpholino-5-androstan-16-yl)pyrrolidinium 17-acetate Molecular Formula: [C32H53N2O4]+ Literature References: Aminosteroid, competitive neuromuscular blocker. Prepn: D. S. Savage et al., EP 287150; T. Sleigh et al., US 4894369 (1988, 1990 both to Akzo). Pharmacology: A. W. Muir et al., Br. J. Anaesth. 63, 400 (1989); K. Khuenl-Brady et al., Anesthesiology 72, 669 (1990). Clinical pharmacodynamics: T. J. Quill et al., Anesth. Analg. 72, 203 (1991); and pharmacokinetics in the elderly: R. S. Matteo et al., ibid. 77, 1193 (1993). Comparative clinical trial: T. Magorian et al., Anesthesiology 79, 913 (1993). HPLC determn: U. W. Kleef et al., J. Chromatogr. 621, 65 (1993). Review: T. C. Wicks, J. Am. Assoc. Nurse Anesth. 62, 33-38 (1994). Derivative Type: Bromide CAS Registry Number: 119302-91-9 Molecular Formula: C32H53BrN2O4 Molecular Weight: 609.68 Percent Composition: C 63.04%, H 8.76%, Br 13.11%, N 4.59%, O 10.50% Properties: Crystals, mp 161-169°. []D20 +18.7° (c = 1.03 in CHCl3). Melting point: mp 161-169° Optical Rotation: []D20 +18.7° (c = 1.03 in CHCl3) Therap-Cat: Neuromuscular blocking agent. Keywords: Neuromuscular Blocking Agent; Nondepolarizing Agents.